충남대학교 생명시스템과학대학 | 교수진

이름

김경미 (Kyoung Mi Kim)

전공

분자생물

연락처

042-821-5498

연구실

노화생물학실험실 (생명시스템과학대학 413호)

경력

2011.09-2013.11: 연구교수, 고려대학교 생명공학연구소
2013.12-2018.11: 박사 후 연구원, Lab of Genetics and Genomics, National Institute on Aging, NIH
2019.09-현재: 충남대학교 생물과학과 조교수

관심분야

◎ 세포노화 (Cellular senescence)의 분자기전 연구
- 세포노화 동안 변화하는 Transcripts 발굴
- RNA 및 RNA-binding protein (RBP)의 세포노화 조절 기능 연구

◎ Extracellular vesicle (EV)의 생성, 분비, 흡수기전 연구

◎ 노화세포 (Senescent cell)로부터 분비되는 EV의 기능 연구
- RNA 및 단백질 구성요소 발굴
- Age-related disease biomarker 발굴

연구업적

Google scholar: https://scholar.google.com/citations?user=v1Fb2M0AAAAJ&hl=en

1.	Kim CH, Lee WJ, Oh Y, Lee Y, Lee HK, Seong JB, Lim KS, Park SJ, Huh JW, Kim YH, Kim KM#, Hur JK#, Lee SH#. (Feb 2024) Utilization of nicking properties of CRISPR-Cas12a effector for genome editing. Sci Rep, 14(1):3352.
 
2.	Koh D, Jeon HB, Oh C, Noh JH, Kim KM. (Sep 2023) RNA-binding proteins in cellular senescence. Mech Ageing Dev, 214:111853.

3.	Sung WJ, Kim D, Zhu A, Cho N, Yoo HM, Noh JH, Kim KM, Lee HS, Hong J. (Nov 2022) The lysosome as a novel therapeutic target of EGFR-mediated tumor inflammation. Front Pharmacol, 13:1050758.

4.	Yao Y, Ren Z, Yang R, Mei Y, Dai Y, Cheng Q, Xu C, Xu X, Wang S, Kim KM, Noh JH, Zhu J, Zhao N, Liu YU, Mao G, Sima J. (Nov 2022) Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway. Cell Biosci, 12(1):180.

5.	Oh C, Koh D, Jeon HB, Kim KM. (Sep 2022) The Role of Extracellular Vesicles in Senescence. Mol Cells, 45(9):603-609.

6.	Kim KM*, Meng Q*, Perez de Acha O, Mustapic M, Cheng A, Eren E, Kundu G, Piao Y, Munk R, Wood III WH, De S, Noh JH, Delannoy M, Cheng L, Abdelmohsen K, Kapogiannis D, Gorospe M. (Nov 2020) Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles. Front. Cell Dev. Biol, 8:581882. (*: equally contributed)
(https://irp.nih.gov/blog/post/2021/02/alzheimer-s-patients-show-traces-of-cellular-batteries-in-blood)

7.	Pandey PR, Yang JH, Tsitsipatis D, Panda AC, Noh JH, Kim KM, Munk R, Nicholson T, Hanniford D, Argibay D, Yang X, Martindale JL, Chang MW, Jones SW, Hernando E, Sen P, De S, Abdelmohsen K, Gorospe M. (Apr 2020) circSamd4 represses myogenic transcriptional activity of PUR proteins. Nucleic Acids Res, 48(7):3789-3805.

8.	Casella G, Munk R, Kim KM, Piao Y, De S, Abdelmohsen K, Gorospe M. (Aug 2019) Transcriptome Signature of Cellular Senescence. Nucleic Acids Res, 47(14):7294-7305.

9.	Noh JH*, Kim KM*, Pandey PR, Noren Hooten N, Munk R, Kundu G, De S, Martindale JL, Yang X, Evans MK, Abdelmohsen K, Gorospe M. (Mar 2019) Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program. Nucleic Acids Res, 47(5):2472-2486. (*: equally contributed)

10.	Munk R*, Kim KM*, Gorospe M, Abdelmohsen K. (Jan 2019) Senescence lncRNAs govern cell surface components: lncRNA-OIS1 transcriptionally elevates DPP4 (Editorial). Non-coding RNA investigation, 3:6. (*: equally contributed)

11.	Noh JH*, Kim KM*, Idda ML*, Martindale JL, Yang X, Abdelmohsen K, Gorospe M. (Aug 2018) GRSF1 suppresses cell senescence. Aging (Albany NY), 10:1856-1866. (*: equally contributed)

12.	Kim KM*#, Noh JH*, Bodogai M, Martindale JL, Pandey PR, Yang X, Biragyn A, Abdelmohsen K, Gorospe M. (Jul 2018) SCAMP4 enhances the senescent cell secretome. Genes and Development, 32(13-14):909-914. (*: equally contributed, #: Corresponding author).

13.	Noh JH, Kim KM, McClusky WG, Abdelmohsen K, Gorospe M. (Mar 2018) Cytoplasmic functions of long noncoding RNAs. Wiley Interdiscip Rev RNA, 9(3): e1471. Review.  

14.	Kim KM*#, Noh JH*, Bodogai M, Martindale JL, Yang X, Indig FE, Basu SK, Ohnuma K, Morimoto C, Johnson PF, Biragyn A, Abdelmohsen K, Gorospe M. (Sept 2017) Identification of senescent cell surface targetable protein DPP4. Genes and Development, 31(15):1529-1534. (*: equally contributed, #: Corresponding author).  

15.	Park J, Park Y, Ryu I, Choi MH, Lee HJ, Oh N, Kim K, Kim KM, Choe J, Lee C, Baik JH, Kim YK. (Jun 2017) Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex. Nat Commun, 8:15730.  

16.	Kim KM#, Abdelmohsen K, Mustapic M, Kapogiannis D, Gorospe M. (Jul 2017) RNA in extracellular vesicles. Wiley Interdiscip Rev RNA, 8(4): e1413. Review. (#: Corresponding author).  

17.	Kim KM, Noh JH, Abdelmohsen K, Gorospe M. (Apr 2017) Mitochondrial noncoding RNA transport. BMB Rep, 50(4):164-174. Review.  

18.	Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL, Gorospe M. (Mar 2017) Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol, 14(3):361-369.  

19.	Panda AC, Grammatikakis I, Kim KM, De S, Martindale JL, Munk R, Yang X, Abdelmohsen K, Gorospe M. (Apr 2017) Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Nucleic Acids Res, 45(7):4021-4035.  

20.	Noh JH*, Kim KM*, Abdelmohsen K, Yoon JH, Panda AC, Munk R, Kim J, Curtis J, Moad CA, Wohler CM, Indig FE, de Paula W, Dudekula DB, De S, Piao Y, Yang X, Martindale JL, de Cabo R, Gorospe M. (May 2016) HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP. Genes and Development, 30(10):1224-39. (*: equally contributed).  

21.	Kim J, Kim KM, Noh JH, Yoon JH, Abdelmohsen K, Gorospe M. (Jan 2016) Long noncoding RNAs in diseases of aging. Biochim Biophys Acta, 1859(1):209-21. Review.  

22.	Abdelmohsen K, Panda AC, De S, Grammatikakis I, Kim J, Ding J, Noh JH, Kim KM, Mattison JA, de Cabo R, Gorospe M. (Nov 2015) Circular RNAs in monkey muscle: age-dependent changes. Aging, 7(11):903-10.  

23.	Yoon JH, De S, Srikantan S, Abdelmohsen K, Grammatikakis I, Kim J, Kim KM, Noh JH, White EJ, Martindale JL, Yang X, Kang MJ, Wood WH 3rd, Noren Hooten N, Evans MK, Becker KG, Tripathi V, Prasanth KV, Wilson GM, Tuschl T, Ingolia NT, Hafner M, Gorospe M. (Nov 2014) PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity. Nat Commun, 5: 5248.  

24.	Cho H, Ahn SH, Kim KM, Kim YK. (Jul 2013) Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1. FEBS Lett, 587(14) 2118-24.  

25.	Choe J*, Kim KM*, Park S, Lee YK, Song OK, Kim MK, Lee BG, Song HK, Kim YK. (Jan 2013) Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20. Nucleic Acids Research, 41(2) 1307–1318. (*: equally contributed).  

26.	Kim KM*, Cho H*, Kim YK. (Aug 2012) The upstream open reading frame of cyclin-dependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame. Biochem. Biophys. Res. Commun, 424(3) 469-475. (*: equally contributed).

27.	Cho H, Kim KM, Han S, Choe J, Park SG, Choi SS, Kim YK. (May 2012) Staufen1-Mediated mRNA Decay Functions in Adipogenesis. Molecular Cell, 46(4):495-506

28.	Kim KM*, Cho H*, Choi K*, Kim J, Kim BW, Ko YG, Jang SK, Kim YK. (Sept 2009) A new MIF4G domain-containing protein CTIF directs nuclear cap-binding protein CBP80/20-dependent translation. Genes and Development, 23:2033-2045. (*: equally contributed).

29.	Cho H*, Kim KM*, Kim YK. (Jan 2009) Human proline-rich nuclear receptor coregulatory protein 2 (PNRC2) mediates an interaction between mRNA surveillance machinery and decapping complex. Molecular Cell, 33(1), 75-86. (*: equally contributed).

30.	Oh N, Kim KM, Choe J, Kim YK. (Oct 2007) Pioneer round of translation mediated by nuclear cap-binding proteins CBP80/20 occurs during prolonged hypoxia. FEBS Lett, 581(26), 5158-5164.

31.	Oh N, Kim KM, Cho H, Choe J, Kim YK. (Oct 2007) Pioneer round of translation occurs during serum starvation. Biochem. Biophys. Res. Commun, 362(1), 145-151.

32.	Kim KM, Kwon SN, Kang JI, Lee SH, Jang SK, Ahn BY, Kim YK. (May 2007) Hepatitis C virus NS2 protein activates cellular cyclic AMP-dependent pathways. Biochem. Biophys. Res. Commun, 356(4):948-54.

33.	You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H. (May 2007) Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. PLOS Biology, 5(5): e109.

Book chapter

Kim K.M.#, Noh J.H., Gorospe M. (2020) Senolysis and Senostasis Through the Plasma Membrane. In: Muñoz-Espin D., Demaria M. (eds) Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-44903-2_7 (#: Corresponding author)